Version 5.4
Mus musculus Protein: Arhgef10l
Summary
InnateDB Protein IDBP-270101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef10l
Protein Name Rho guanine nucleotide exchange factor (GEF) 10-like
Synonyms 2810441C07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000101425
InnateDB Gene IDBG-201081 (Arhgef10l)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1920004
InterPro IPR000219 Dbl homology (DH) domain
IPR017986 WD40-repeat-containing domain
PFAM PF00621
PRINTS
PIRSF
SMART SM00325
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AWP8
PhosphoSite PhosphoSite-A2AWP8
TrEMBL A8Y5U3
UniProt Splice Variant
Entrez Gene 72754
UniGene Mm.29329
RefSeq NP_001277732
MGI ID
MGI Symbol Arhgef10l
OMIM
CCDS CCDS71507
HPRD
IMGT
EMBL AK028648 AK129408 AL929073 AL954710 BC021843 BC059220 BX530090
GenPept AAH21843 AAH59220 BAC26047 BAC98218 CAM14356 CAM14358 CAM14359 CAM14360 CAM14361 CAM14469 CAM14471 CAM14472 CAM14473 CAM14474 CAM19324 CAM19327 CAM19328 CAM19329 CAM19330

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca