InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wasf1

Summary

InnateDB Protein

IDBP-270733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wasf1

Protein Name

WASP family 1

Synonyms

AI195380; AI838537; Scar; WAVE; WAVE-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101148

InnateDB Gene

IDBG-146104 (Wasf1)

Protein Structure

UniProt Annotation

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse {ECO:0000269PubMed:24153177}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. {ECO:0000269PubMed:12062808, ECO:0000269PubMed:24153177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0030036	actin cytoskeleton organization
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005856	cytoskeleton
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0045202	synapse