Version 5.4
Mus musculus Protein: P4ha1
Summary
InnateDB Protein IDBP-270824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4ha1
Protein Name procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
Synonyms AL022634; P4ha;
Species Mus musculus
Ensembl Protein ENSMUSP00000101106
InnateDB Gene IDBG-153605 (P4ha1)
Protein Structure
UniProt Annotation
Function Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Subcellular Localization Endoplasmic reticulum lumen.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199 collagen fibril organization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016222 procollagen-proline 4-dioxygenase complex
Protein Structure and Domains
PDB ID MGI:97463
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
IPR006620 Prolyl 4-hydroxylase, alpha subunit
IPR013026 Tetratricopeptide repeat-containing domain
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
IPR019734 Tetratricopeptide repeat
PFAM PF03171
PF13640
PF08336
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00702
SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60715
PhosphoSite PhosphoSite-Q60715
TrEMBL
UniProt Splice Variant
Entrez Gene 18451
UniGene Mm.2212
RefSeq
MGI ID
MGI Symbol P4ha1
OMIM
CCDS
HPRD
IMGT
EMBL AK045008 AK160798 AK169726 BC009654 U16162
GenPept AAC52197 AAH09654 BAC32183 BAE36020 BAE41331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca