Version 5.4
Homo sapiens Protein: MBOAT2
Summary
InnateDB Protein IDBP-27277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBOAT2
Protein Name membrane bound O-acyltransferase domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302177
InnateDB Gene IDBG-27273 (MBOAT2)
Protein Structure
UniProt Annotation
Function Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18772128}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in neutrophils. {ECO:0000269PubMed:18772128}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZWT7
PhosphoSite PhosphoSite-Q6ZWT7
TrEMBL B0AZU0
UniProt Splice Variant
Entrez Gene 129642
UniGene Hs.712689
RefSeq NP_620154
HUGO HGNC:25193
OMIM 611949
CCDS CCDS1660
HPRD 11410
IMGT
EMBL AB305044 AC012495 AC112723 AK027321 AK074779 AK315881 BC016005 BC146871 BC157827
GenPept AAH16005 AAI46872 AAI57828 BAC11204 BAC85105 BAF93900 BAF98772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca