InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fhl1

Summary

InnateDB Protein

IDBP-273732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fhl1

Protein Name

four and a half LIM domains 1

Synonyms

FHL-1; KyoT; RAM14-1; SLIM; SLIM-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112295

InnateDB Gene

IDBG-146975 (Fhl1)

Protein Structure

UniProt Annotation

Function

May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.

Subcellular Localization

Isoform 1: Cytoplasm.Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 seems to be most abundant in each tissue and isoform 2 much less abundant. Isoform 1 is highly expressed in skeletal muscle and lung, and to a lesser extent in heart, brain and kidney. Isoform 2 was found in brain, lung kidney and genital organs. {ECO:0000269PubMed:10906474}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0044325	ion channel binding

Biological Process

GO:0003254	regulation of membrane depolarization
GO:0007275	multicellular organismal development
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle
GO:0030154	cell differentiation
GO:0030308	negative regulation of cell growth
GO:0043268	positive regulation of potassium ion transport
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle