InnateDB Protein
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IDBP-273956.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cep55
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Protein Name
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centrosomal protein 55
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Synonyms
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1200008O12Rik; 2700032M20Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112205
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InnateDB Gene
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IDBG-162559 (Cep55)
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Protein Structure
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Function |
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. Dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921357
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InterPro |
IPR022008
TSG101 and ALIX binding domain of CEP55
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PFAM |
PF12180
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BT07
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PhosphoSite |
PhosphoSite-Q8BT07
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
74107
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UniGene |
Mm.9916
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RefSeq |
NP_083036
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MGI ID |
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MGI Symbol |
Cep55
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OMIM |
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CCDS |
CCDS29782
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HPRD |
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IMGT |
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EMBL |
AK004655
AK028216
AK088548
BC026966
BC031396
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GenPept |
AAH26966
AAH31396
BAB23446
BAC25819
BAC40417
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