InnateDB Protein
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IDBP-273991.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ubp1
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Protein Name
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upstream binding protein 1
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Synonyms
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Cp2b; LBP-1a; LBP-1b; NF2d9;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112192
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InnateDB Gene
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IDBG-203220 (Ubp1)
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Protein Structure
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Function |
Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha- globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highly expressed in erythroid cells. {ECO:0000269PubMed:15988015, ECO:0000269PubMed:7623810}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104889
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InterPro |
IPR007604
CP2 transcription factor
IPR013761
Sterile alpha motif/pointed domain
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PFAM |
PF04516
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q811S7
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PhosphoSite |
PhosphoSite-Q811S7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22221
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UniGene |
Mm.396708
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RefSeq |
XP_006512115
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MGI ID |
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MGI Symbol |
Ubp1
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OMIM |
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CCDS |
CCDS40789
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HPRD |
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IMGT |
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EMBL |
AK079815
AK140942
AK143282
AY182062
BC139828
U20086
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GenPept |
AAC52244
AAI39829
AAO24130
BAC37754
BAE24526
BAE25332
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