Mus musculus Protein: Ell3
InnateDB Protein IDBP-274144.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ell3
Protein Name elongation factor RNA polymerase II-like 3
Species Mus musculus
Ensembl Protein ENSMUSP00000112133
InnateDB Gene IDBG-202326 (Ell3)
Protein Structure
UniProt Annotation
Function Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P- TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). {ECO:0000269PubMed:22768269, ECO:0000269PubMed:23273992}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23273992}.
Disease Associations
Tissue Specificity Actively expressed in embryonic stem cells (ES cells), while it is weakly expressed in differentiated cells. {ECO:0000269PubMed:22768269}.
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035326 enhancer binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048863 stem cell differentiation
GO:0050769 positive regulation of neurogenesis
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0008023 transcription elongation factor complex
Protein Structure and Domains
PDB ID MGI:2673679
InterPro IPR010844 Occludin/RNA polymerase II elongation factor, ELL domain
IPR019464 RNA polymerase II elongation factor ELL
PFAM PF07303
Post-translational Modifications
SwissProt Q80VR2
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 269344
UniGene Mm.488519
RefSeq NP_666085
MGI Symbol Ell3
EMBL AL845466 BC045151
GenPept AAH45151 CAM24232