InnateDB Protein
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IDBP-274144.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ell3
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Protein Name
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elongation factor RNA polymerase II-like 3
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112133
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InnateDB Gene
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IDBG-202326 (Ell3)
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Protein Structure
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Function |
Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P- TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). {ECO:0000269PubMed:22768269, ECO:0000269PubMed:23273992}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:23273992}.
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Disease Associations |
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Tissue Specificity |
Actively expressed in embryonic stem cells (ES cells), while it is weakly expressed in differentiated cells. {ECO:0000269PubMed:22768269}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006368
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transcription elongation from RNA polymerase II promoter
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GO:0010717
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regulation of epithelial to mesenchymal transition
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GO:0032786
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positive regulation of DNA-templated transcription, elongation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048863
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stem cell differentiation
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GO:0050769
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positive regulation of neurogenesis
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GO:1901797
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negative regulation of signal transduction by p53 class mediator
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GO:1902166
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negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:2000179
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positive regulation of neural precursor cell proliferation
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Cellular Component |
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PDB ID |
MGI:2673679
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InterPro |
IPR010844
Occludin/RNA polymerase II elongation factor, ELL domain
IPR019464
RNA polymerase II elongation factor ELL
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PFAM |
PF07303
PF10390
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q80VR2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
269344
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UniGene |
Mm.488519
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RefSeq |
NP_666085
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MGI ID |
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MGI Symbol |
Ell3
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OMIM |
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CCDS |
CCDS16644
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HPRD |
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IMGT |
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EMBL |
AL845466
BC045151
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GenPept |
AAH45151
CAM24232
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