InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rcor1

Summary

InnateDB Protein

IDBP-274247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rcor1

Protein Name

REST corepressor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112089

InnateDB Gene

IDBG-172449 (Rcor1)

Protein Structure

UniProt Annotation

Function

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269PubMed:15907476, ECO:0000269PubMed:17707228, ECO:0000269PubMed:20346398}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624}.

Disease Associations

Tissue Specificity

Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum and in Purkinje cells (at protein level). {ECO:0000269PubMed:20346398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030218	erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0070933	histone H4 deacetylation