InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctc1

Summary

InnateDB Protein

IDBP-274313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctc1

Protein Name

RIKEN cDNA 1500010J02 gene

Synonyms

1500010J02Rik; AAF-132; AAF132;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112063

InnateDB Gene

IDBG-189510 (Ctc1)

Protein Structure

UniProt Annotation

Function

Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269PubMed:19854130}.

Subcellular Localization

Nucleus. Chromosome, telomere. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0000723	telomere maintenance
GO:0006974	cellular response to DNA damage stimulus
GO:0007568	aging
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0010833	telomere maintenance via telomere lengthening
GO:0035264	multicellular organism growth
GO:0045740	positive regulation of DNA replication
GO:0048146	positive regulation of fibroblast proliferation
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048539	bone marrow development
GO:0051276	chromosome organization
GO:0071425	hematopoietic stem cell proliferation
GO:0090399	replicative senescence