InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX1B

Summary

InnateDB Protein

IDBP-27545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX1B

Protein Name

syntaxin 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215095

InnateDB Gene

IDBG-27543 (STX1B)

Protein Structure

UniProt Annotation

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Membrane {ECO:0000305}; Single- pass type IV membrane protein {ECO:0000305}.Isoform 2: Nucleus {ECO:0000269PubMed:18691641}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18691641}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:18691641}. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0017157	regulation of exocytosis
GO:0034220	ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane