InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYT4

Summary

InnateDB Protein

IDBP-2755.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT4

Protein Name

synaptotagmin IV

Synonyms

HsT1192;

Species

Homo sapiens

Ensembl Protein

ENSP00000255224

InnateDB Gene

IDBG-2753 (SYT4)

Protein Structure

UniProt Annotation

Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0001786	phosphatidylserine binding
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030276	clathrin binding

Biological Process

GO:0006887	exocytosis
GO:0007269	neurotransmitter secretion
GO:0031339	negative regulation of vesicle fusion
GO:0045955	negative regulation of calcium ion-dependent exocytosis

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm