InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PON2

Summary

InnateDB Protein

IDBP-27760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PON2

Protein Name

paraoxonase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222572

InnateDB Gene

IDBG-27758 (PON2)

Protein Structure

UniProt Annotation

Function

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. {ECO:0000269PubMed:11579088, ECO:0000269PubMed:15772423}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11579088}; Peripheral membrane protein {ECO:0000269PubMed:11579088}.

Disease Associations

Tissue Specificity

Widely expressed with highest expression in liver, lung, placenta, testis and heart. {ECO:0000269PubMed:11579088}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004064	arylesterase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006979	response to oxidative stress
GO:0008152	metabolic process
GO:0019439	aromatic compound catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle