InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC28A1

Summary

InnateDB Protein

IDBP-27825.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC28A1

Protein Name

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

Synonyms

CNT1; HCNT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000341629

InnateDB Gene

IDBG-27821 (SLC28A1)

Protein Structure

UniProt Annotation

Function

Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0005337	nucleoside transmembrane transporter activity
GO:0005415	nucleoside:sodium symporter activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0015858	nucleoside transport
GO:0055085	transmembrane transport
GO:1901642	nucleoside transmembrane transport