Version 5.4
Homo sapiens Protein: ANKRA2
Summary
InnateDB Protein IDBP-28112.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKRA2
Protein Name ankyrin repeat, family A (RFXANK-like), 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296785
InnateDB Gene IDBG-28108 (ANKRA2)
Protein Structure
UniProt Annotation
Function May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H9E1
PhosphoSite PhosphoSite-Q9H9E1
TrEMBL A0A024RAN7
UniProt Splice Variant
Entrez Gene 57763
UniGene Hs.627340
RefSeq NP_075526
HUGO HGNC:13208
OMIM 605787
CCDS CCDS4020
HPRD 12044
IMGT
EMBL AF251051 AF314032 AK022876 BC012917 CH471084
GenPept AAH12917 AAK01621 AAK34941 BAB14288 EAW95729 EAW95730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca