InnateDB Protein
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IDBP-28120.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PYDC1
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Protein Name
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PYD (pyrin domain) containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000304336
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InnateDB Gene
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IDBG-28118 (PYDC1)
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Protein Structure
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Function |
Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269PubMed:12656673}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12656673}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269PubMed:12656673}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006469
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negative regulation of protein kinase activity
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GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0033209
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tumor necrosis factor-mediated signaling pathway
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GO:0045087
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innate immune response
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GO:0050718
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positive regulation of interleukin-1 beta secretion
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Cellular Component |
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PDB ID |
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InterPro |
IPR004020
DAPIN domain
IPR011029
Death-like domain
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PFAM |
PF02758
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WXC3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
260434
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UniGene |
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RefSeq |
NP_690865
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HUGO |
HGNC:30261
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OMIM |
615700
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CCDS |
CCDS10710
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HPRD |
17938
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IMGT |
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EMBL |
AF454669
AF467809
AK313418
AY163727
BC105033
BC105035
CH471192
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GenPept |
AAI05034
AAI05036
AAL58439
AAN03745
AAO23114
BAG36211
EAW52147
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