InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJC15

Summary

InnateDB Protein

IDBP-28548.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC15

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368523

InnateDB Gene

IDBG-28544 (DNAJC15)

Protein Structure

UniProt Annotation

Function

Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269PubMed:23263864}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:23263864, ECO:0000269PubMed:23530063}; Single-pass membrane protein {ECO:0000269PubMed:23263864, ECO:0000269PubMed:23530063}.

Disease Associations

Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

Tissue Specificity

Expressed at highest levels in heart, followed by liver and kidney. {ECO:0000269PubMed:11358853, ECO:0000269PubMed:23530063}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0009267	cellular response to starvation
GO:0015031	protein transport
GO:0019216	regulation of lipid metabolic process
GO:0031333	negative regulation of protein complex assembly
GO:1902957	negative regulation of mitochondrial electron transport, NADH to ubiquinone