InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AEN

Summary

InnateDB Protein

IDBP-28672.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AEN

Protein Name

apoptosis enhancing nuclease

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000331944

InnateDB Gene

IDBG-28670 (AEN)

Protein Structure

UniProt Annotation

Function

Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269PubMed:16171785, ECO:0000269PubMed:18264133}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity

Biological Process

GO:0010212	response to ionizing radiation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0090305	nucleic acid phosphodiester bond hydrolysis