Version 5.4
Homo sapiens Protein: AHSP
Summary
InnateDB Protein IDBP-28680.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AHSP
Protein Name alpha hemoglobin stabilizing protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000307199
InnateDB Gene IDBG-28678 (AHSP)
Protein Structure
UniProt Annotation
Function Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. {ECO:0000269PubMed:12066189}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12066189}.
Disease Associations
Tissue Specificity Expressed in blood and bone marrow. {ECO:0000269PubMed:11231637, ECO:0000269PubMed:12066189}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030492 hemoglobin binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0020027 hemoglobin metabolic process
GO:0030097 hemopoiesis
GO:0050821 protein stabilization
Cellular Component
GO:0005833 hemoglobin complex
Protein Structure and Domains
PDB ID
InterPro IPR015317 Alpha-haemoglobin stabilising protein
PFAM PF09236
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZD4
PhosphoSite PhosphoSite-
TrEMBL Q549J4
UniProt Splice Variant
Entrez Gene 51327
UniGene Hs.274309
RefSeq NP_057717
HUGO HGNC:18075
OMIM 605821
CCDS CCDS10716
HPRD 12052
IMGT
EMBL AC106730 AF112995 AF208865 AF364517 AF485325 AY072612 BC035842 CH471192
GenPept AAF64279 AAH35842 AAK50856 AAL82894 AAO49381 AAP97228 EAW52118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca