Version 5.4
Homo sapiens Protein: SLC10A6
Summary
InnateDB Protein IDBP-28697.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC10A6
Protein Name solute carrier family 10 (sodium/bile acid cotransporter family), member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000273905
InnateDB Gene IDBG-28695 (SLC10A6)
Protein Structure
UniProt Annotation
Function Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. {ECO:0000269PubMed:17491011}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus. {ECO:0000269PubMed:17491011}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008508 bile acid:sodium symporter activity
GO:0043250 sodium-dependent organic anion transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0043251 sodium-dependent organic anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002657 Bile acid:sodium symporter
IPR004710 Bile acid transporter
PFAM PF01758
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3KNW5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 345274
UniGene Hs.452996
RefSeq NP_932069
HUGO HGNC:30603
OMIM 613366
CCDS CCDS3614
HPRD 11593
IMGT
EMBL AJ583502 BC107051 BC107052 CH471057 EF437223
GenPept AAI07052 AAI07053 ABO38126 CAE47477 EAX05969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca