Version 5.4
Homo sapiens Protein: SUN1
Summary
InnateDB Protein IDBP-292458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUN1
Protein Name Sad1 and UNC84 domain containing 1
Synonyms UNC84A;
Species Homo sapiens
Ensembl Protein ENSP00000383947
InnateDB Gene IDBG-6219 (SUN1)
Protein Structure
UniProt Annotation
Function Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus inner membrane {ECO:0000269PubMed:12958361, ECO:0000269PubMed:16445915, ECO:0000269PubMed:17132086, ECO:0000269PubMed:18845190, ECO:0000269PubMed:19933576}; Single-pass type II membrane protein {ECO:0000269PubMed:12958361, ECO:0000269PubMed:16445915, ECO:0000269PubMed:17132086, ECO:0000269PubMed:18845190, ECO:0000269PubMed:19933576}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0090286 cytoskeletal anchoring at nuclear membrane
GO:0090292 nuclear matrix anchoring at nuclear membrane
Cellular Component
GO:0005635 nuclear envelope
GO:0005639 integral component of nuclear inner membrane
GO:0034993 SUN-KASH complex
Protein Structure and Domains
PDB ID
InterPro IPR018539 SUN domain-containing protein 1
PFAM PF09387
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O94901
PhosphoSite PhosphoSite-O94901
TrEMBL C9K051
UniProt Splice Variant
Entrez Gene 23353
UniGene Hs.708379
RefSeq NP_001165417
HUGO HGNC:18587
OMIM 607723
CCDS CCDS55079
HPRD 16257
IMGT
EMBL AB018353 AC073957 AC099731 AF202724 AK022469 AK022816 AK302896 AK309120 BC013613 BC142707 BX538211
GenPept AAF15888 AAH13613 AAI42708 BAA34530 BAB14046 BAG51119 BAG64069 CAD98070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca