InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDIA2

Summary

InnateDB Protein

IDBP-292514.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDIA2

Protein Name

protein disulfide isomerase family A, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384410

InnateDB Gene

IDBG-7384 (PDIA2)

Protein Structure

UniProt Annotation

Function

Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. {ECO:0000269PubMed:19150607, ECO:0000269PubMed:19429457}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.

Disease Associations

Tissue Specificity

Highly expressed in pancreas (at protein level). {ECO:0000269PubMed:19429457, ECO:0000269PubMed:8561901, ECO:0000269PubMed:9115635}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0006457	protein folding
GO:0006621	protein retention in ER lumen
GO:0019511	peptidyl-proline hydroxylation
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway