InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKD

Summary

InnateDB Protein

IDBP-292886.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKD

Protein Name

diacylglycerol kinase, delta 130kDa

Synonyms

dgkd-2; DGKdelta;

Species

Homo sapiens

Ensembl Protein

ENSP00000386455

InnateDB Gene

IDBG-83485 (DGKD)

Protein Structure

UniProt Annotation

Function

May function as signaling molecule. {ECO:0000269PubMed:17880279}.Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. {ECO:0000269PubMed:17880279}.

Subcellular Localization

Isoform 2: Cytoplasm.Isoform 1: Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells. {ECO:0000269PubMed:12200442}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019992	diacylglycerol binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0010033	response to organic substance
GO:0015031	protein transport
GO:0016049	cell growth
GO:0016310	phosphorylation
GO:0019932	second-messenger-mediated signaling
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0046339	diacylglycerol metabolic process
GO:0051260	protein homooligomerization

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF00609
PF00781
PF00169
PF00130
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00045
SM00046
SM00454
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16760