InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESR1

Summary

InnateDB Protein

IDBP-293110.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESR1

Protein Name

estrogen receptor 1

Synonyms

ER; Era; ESR; ESRA; ESTRR; NR3A1;

Species

Homo sapiens

Ensembl Protein

ENSP00000384064

InnateDB Gene

IDBG-97997 (ESR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 764 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	764 [view]
Protein-Protein	728 [view]
Protein-DNA	27 [view]
Protein-RNA	1 [view]
DNA-DNA	8 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005496	steroid binding
GO:0030284	estrogen receptor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001292 Oestrogen receptor
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF02159

PRINTS

PR00543
PR00398

PIRSF

PIRSF500101

SMART

SM00430

TIGRFAMs

Post-translational Modifications

Modification

Cross-References