InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPP4

Summary

InnateDB Protein

IDBP-293161.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPP4

Protein Name

membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387278

InnateDB Gene

IDBG-78725 (MPP4)

Protein Structure

UniProt Annotation

Function

May play a role in retinal photoreceptors development. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15914641}. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).

Disease Associations

Tissue Specificity

Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific. {ECO:0000269PubMed:11414766, ECO:0000269PubMed:12384283, ECO:0000269PubMed:15558731, ECO:0000269PubMed:15914641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0035418

protein localization to synapse

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0042734	presynaptic membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR004172 L27
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR014775 L27, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM