Version 5.4
Homo sapiens Protein: NAB1
Summary
InnateDB Protein IDBP-293290.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAB1
Protein Name NGFI-A binding protein 1 (EGR1 binding protein 1)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387089
InnateDB Gene IDBG-77557 (NAB1)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform Short is found in myeloid leukemia cell line KG-1.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006986 Nab1, C-terminal
IPR006988 Nab, N-terminal
IPR006989 NAB co-repressor, domain
IPR013761 Sterile alpha motif/pointed domain
PFAM PF04902
PF04904
PF04905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13506
PhosphoSite PhosphoSite-Q13506
TrEMBL C9JL92
UniProt Splice Variant
Entrez Gene 4664
UniGene Hs.730686
RefSeq
HUGO HGNC:7626
OMIM 600800
CCDS CCDS2307
HPRD 02881
IMGT
EMBL AC006460 AF045451 AF045452 AF052744 BC035724 U47007
GenPept AAC25085 AAC25086 AAC28325 AAC50588 AAH35724 AAX93076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca