InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PMS1

Summary

InnateDB Protein

IDBP-293315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PMS1

Protein Name

PMS1 postmeiotic segregation increased 1 (S. cerevisiae)

Synonyms

HNPCC3; hPMS1; PMSL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000387125

InnateDB Gene

IDBG-77409 (PMS1)

Protein Structure

UniProt Annotation

Function

Probably involved in the repair of mismatches in DNA. {ECO:0000269PubMed:10748105}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	51 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030983	mismatched DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006298	mismatch repair

Cellular Component

GO:0005634	nucleus
GO:0032389	MutLalpha complex

Protein Structure and Domains

PDB ID

InterPro

IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR009071 High mobility group box domain
IPR013507 DNA mismatch repair protein, C-terminal
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF02518
PF13581
PF00505
PF09011
PF01119

PRINTS

PIRSF

SMART

SM00387
SM00398

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54277