InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFPI

Summary

InnateDB Protein

IDBP-293330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFPI

Protein Name

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

Synonyms

EPI; LACI; TFI; TFPI1;

Species

Homo sapiens

Ensembl Protein

ENSP00000386344

InnateDB Gene

IDBG-77150 (TFPI)

Protein Structure

UniProt Annotation

Function

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Subcellular Localization

Isoform Alpha: Secreted.Isoform Beta: Microsome membrane {ECO:0000269PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:22144186}.

Disease Associations

Tissue Specificity

Mostly in endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0007596	blood coagulation
GO:0007598	blood coagulation, extrinsic pathway
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0031090	organelle membrane
GO:0031225	anchored component of membrane