InnateDB Protein
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IDBP-293363.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNRC6B
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Protein Name
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trinucleotide repeat containing 6B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384795
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InnateDB Gene
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IDBG-8635 (TNRC6B)
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Protein Structure
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Function |
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269PubMed:16289642, ECO:0000269PubMed:19167051, ECO:0000269PubMed:19304925, ECO:0000269PubMed:21981923}.
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Subcellular Localization |
Cytoplasm, P-body {ECO:0000269PubMed:16289642, ECO:0000269PubMed:19167051}. Note=Mammalian P-bodies are also known as GW bodies (GWBs).
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
43
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006417
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regulation of translation
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GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0007219
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Notch signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0010467
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gene expression
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GO:0031047
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gene silencing by RNA
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0045087
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innate immune response
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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GO:0060213
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positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
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GO:1900153
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positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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Cellular Component |
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PDB ID |
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InterPro |
IPR009060
UBA-like
IPR019486
Argonaute hook domain
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PFAM |
PF10427
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UPQ9
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PhosphoSite |
PhosphoSite-Q9UPQ9
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TrEMBL |
B0QYM5
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UniProt Splice Variant |
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Entrez Gene |
23112
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UniGene |
Hs.710774
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RefSeq |
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HUGO |
HGNC:29190
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OMIM |
610740
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CCDS |
CCDS46712
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HPRD |
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IMGT |
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EMBL |
AB029016
AK294519
AL022238
AL031589
AL033547
BC028626
CH471095
Z83847
Z93783
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GenPept |
AAH28626
BAA83045
BAG57731
CAQ07207
CAQ07209
CAQ08008
CAQ08010
CAQ08927
CAQ08932
EAW60367
EAW60371
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