Homo sapiens Protein: CACNA1I | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-293385.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CACNA1I | ||||||||||||||||||
Protein Name | calcium channel, voltage-dependent, T type, alpha 1I subunit | ||||||||||||||||||
Synonyms | ca(v)3.3; Cav3.3; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000384093 | ||||||||||||||||||
InnateDB Gene | IDBG-8474 (CACNA1I) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Brain specific. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002077
Voltage-dependent calcium channel, alpha-1 subunit IPR005445 Voltage-dependent calcium channel, T-type, alpha-1 subunit IPR005821 Ion transport domain IPR013122 Polycystin cation channel, PKD1/PKD2 |
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PFAM |
PF00520
PF08016 |
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PRINTS |
PR00167
PR01629 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9P0X4 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9P0X4 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8911 | ||||||||||||||||||
UniGene | Hs.125116 | ||||||||||||||||||
RefSeq | NP_001003406 | ||||||||||||||||||
HUGO | HGNC:1396 | ||||||||||||||||||
OMIM | 608230 | ||||||||||||||||||
CCDS | CCDS46711 | ||||||||||||||||||
HPRD | 10500 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB032946 AF129133 AF142567 AF211189 AF393329 AL008716 AL022312 AL022319 | ||||||||||||||||||
GenPept | AAD45251 AAF25722 AAF44626 AAM67414 BAA86434 CAI17903 CAI19180 CAI19662 CAQ08289 CAQ08290 CAQ08291 CAQ09516 CAQ09517 CAQ09518 CAQ09681 CAQ09682 CAQ09683 | ||||||||||||||||||