InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GP5

Summary

InnateDB Protein

IDBP-293485.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GP5

Protein Name

glycoprotein V (platelet)

Synonyms

CD42d; GPV;

Species

Homo sapiens

Ensembl Protein

ENSP00000383931

InnateDB Gene

IDBG-70270 (GP5)

Protein Structure

UniProt Annotation

Function

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Platelets and megakaryocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0010544	negative regulation of platelet activation
GO:0030168	platelet activation