InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO3B

Summary

InnateDB Protein

IDBP-293692.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO3B

Protein Name

myosin IIIB

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386213

InnateDB Gene

IDBG-74634 (MYO3B)

Protein Structure

UniProt Annotation

Function

Probable actin-based motor with a protein kinase activity.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Expressed in retina, kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0046777	protein autophosphorylation
GO:0050896	response to stimulus
GO:0051491	positive regulation of filopodium assembly

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0016459	myosin complex
GO:0032426	stereocilium bundle tip
GO:0032433	filopodium tip

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001609 Myosin head, motor domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00069
PF07714
PF00063

PRINTS

PR00109
PR00193

PIRSF

SMART

SM00015
SM00242
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt