InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCN7A

Summary

InnateDB Protein

IDBP-293775.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN7A

Protein Name

sodium channel, voltage-gated, type VII, alpha

Synonyms

NaG; Nav2.1; Nav2.2; SCN6A;

Species

Homo sapiens

Ensembl Protein

ENSP00000386796

InnateDB Gene

IDBG-74239 (SCN7A)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Heart and uterus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006936	muscle contraction
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055078	sodium ion homeostasis
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential