Version 5.4
Homo sapiens Protein: FAM168B
Summary
InnateDB Protein IDBP-294234.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM168B
Protein Name family with sequence similarity 168, member B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387051
InnateDB Gene IDBG-70043 (FAM168B)
Protein Structure
UniProt Annotation
Function Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level). {ECO:0000269PubMed:20716133}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1KXE4
PhosphoSite PhosphoSite-NP_001009993
TrEMBL A0A024QZ31
UniProt Splice Variant
Entrez Gene 130074
UniGene Hs.627022
RefSeq NP_001009993
HUGO HGNC:27016
OMIM
CCDS CCDS42755
HPRD 17295
IMGT
EMBL AY253283 BC066347 BC110642 CH471250
GenPept AAH66347 AAI10643 AAP79599 EAW51267 EAW51268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca