InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HENMT1

Summary

InnateDB Protein

IDBP-294382.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HENMT1

Protein Name

HEN1 methyltransferase homolog 1 (Arabidopsis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385655

InnateDB Gene

IDBG-100681 (HENMT1)

Protein Structure

UniProt Annotation

Function

Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0008171	O-methyltransferase activity
GO:0008173	RNA methyltransferase activity
GO:0046872	metal ion binding