InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIF

Summary

InnateDB Protein

IDBP-294599.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIF

Protein Name

leukemia inhibitory factor (cholinergic differentiation factor)

Synonyms

CDF; DIA; HILDA; MLPLI;

Species

Homo sapiens

Ensembl Protein

ENSP00000384450

InnateDB Gene

IDBG-3968 (LIF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001135	RNA polymerase II transcription factor recruiting transcription factor activity
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005146	leukemia inhibitory factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045651	positive regulation of macrophage differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046888	negative regulation of hormone secretion
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182	positive regulation of protein localization to nucleus
GO:1901676	positive regulation of histone H3-K27 acetylation