InnateDB Protein
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IDBP-294619.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPP10
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Protein Name
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dipeptidyl-peptidase 10 (non-functional)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386565
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InnateDB Gene
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IDBG-67408 (DPP10)
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Protein Structure
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Function |
Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. {ECO:0000269PubMed:12662155, ECO:0000269PubMed:15454437, ECO:0000269PubMed:15671030}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:12662155, ECO:0000269PubMed:14566338}; Single-pass type II membrane protein {ECO:0000269PubMed:12662155, ECO:0000269PubMed:14566338}.
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Disease Associations |
Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269PubMed:14566338, ECO:0000269PubMed:19237393}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands. {ECO:0000269PubMed:12662155, ECO:0000269PubMed:14566338}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008236
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serine-type peptidase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001375
Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469
Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF00326
PF00930
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N608
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PhosphoSite |
PhosphoSite-Q8N608
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TrEMBL |
Q53TB1
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UniProt Splice Variant |
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Entrez Gene |
57628
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UniGene |
Hs.657379
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RefSeq |
NP_065919
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HUGO |
HGNC:20823
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OMIM |
608209
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CCDS |
CCDS46400
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HPRD |
07083
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IMGT |
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EMBL |
AB040925
AC010885
AC012071
AC016721
AC017040
AC066593
AC067947
AC068542
AC093610
AC105422
AC116620
AC118276
AC118664
AK289967
AY172661
AY387785
BC030832
DQ857322
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GenPept |
AAH30832
AAO17263
AAQ91190
AAY14685
AAY14930
AAY15025
AAY15032
AAY24120
ABI16086
BAA96016
BAF82656
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