InnateDB Protein
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IDBP-294633.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM214
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Protein Name
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transmembrane protein 214
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384417
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InnateDB Gene
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IDBG-36463 (TMEM214)
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Protein Structure
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Function |
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress. {ECO:0000269PubMed:23661706}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:23661706}; Multi-pass membrane protein {ECO:0000269PubMed:23661706}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019308
Protein of unknown function DUF2359, TMEM214
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PFAM |
PF10151
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NUQ4
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PhosphoSite |
PhosphoSite-Q6NUQ4
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TrEMBL |
B2RD07
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UniProt Splice Variant |
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Entrez Gene |
54867
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UniGene |
Hs.533934
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RefSeq |
NP_001077059
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HUGO |
HGNC:25983
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OMIM |
615301
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CCDS |
CCDS46242
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HPRD |
07887
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IMGT |
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EMBL |
AC013472
AF289555
AK000261
AK074981
AK097308
AK315359
AL833725
BC068479
CH471053
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GenPept |
AAH68479
AAL55739
AAY14654
BAA91038
BAC11331
BAG37754
BAG53451
CAH10591
EAX00655
EAX00657
EAX00659
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