InnateDB Protein
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IDBP-294704.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IPO11
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Protein Name
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importin 11
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386992
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InnateDB Gene
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IDBG-23349 (IPO11)
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Protein Structure
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Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11032817}. Nucleus {ECO:0000269PubMed:11032817}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
45
[view]
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Protein-Protein |
45
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001494
Importin-beta, N-terminal domain
IPR016024
Armadillo-type fold
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PFAM |
PF03810
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PRINTS |
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PIRSF |
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SMART |
SM00913
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UI26
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PhosphoSite |
PhosphoSite-Q9UI26
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TrEMBL |
E7EMB7
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UniProt Splice Variant |
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Entrez Gene |
51194
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UniGene |
Hs.609826
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RefSeq |
NP_001128251
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HUGO |
HGNC:20628
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OMIM |
610889
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CCDS |
CCDS47217
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HPRD |
18066
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IMGT |
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EMBL |
AC008859
AC016637
AC114982
AF111109
AK001696
AK302781
AL162083
BC031694
BC033776
CH471137
FJ695194
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GenPept |
AAF21936
AAH31694
AAH33776
BAA91843
BAG63985
CAB82416
EAW51379
EAW51380
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