Version 5.4
Homo sapiens Protein: MACROD2
Summary
InnateDB Protein IDBP-294901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MACROD2
Protein Name MACRO domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385516
InnateDB Gene IDBG-55088 (MACROD2)
Protein Structure
UniProt Annotation
Function Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. {ECO:0000269PubMed:21257746, ECO:0000269PubMed:23474712}.
Subcellular Localization Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019213 deacetylase activity
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0042278 purine nucleoside metabolic process
GO:0051725 protein de-ADP-ribosylation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1Z1Q3
PhosphoSite PhosphoSite-A1Z1Q3
TrEMBL
UniProt Splice Variant
Entrez Gene 140733
UniGene Hs.661576
RefSeq
HUGO HGNC:16126
OMIM 611567
CCDS
HPRD 16640
IMGT
EMBL AC006198 AK125899 AK131348 AL035073 AL049633 AL049867 AL050324 AL079338 AL117333 AL118503 AL118510 AL121582 AL121584 AL132826 AL133462 AL136991 AL136992 AL138808 AL139825 AL158088 AL161800 AL353798 AL354773 AL355133 AL357654 BC018687 BC035876 BC101216 BC101217 BC101218 BC101219 BC126936 CH471133 EF159161
GenPept AAH18687 ABM46908 BAD18504 BAG54262 CAH71976 CAI16368 CAM14046 CAM18337 CAM26942 CAM27056 CAM27329 CAM28281 CAM28328 CAM28330 CAQ06880 CAQ06881 CAQ07295 CAQ08720 CAQ08721 EAX10293 EAX10302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca