Version 5.4
Homo sapiens Protein: IL6
Summary
InnateDB Protein IDBP-294915.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL6
Protein Name interleukin 6 (interferon, beta 2)
Synonyms BSF2; HGF; HSF; IFNB2; IL-6;
Species Homo sapiens
Ensembl Protein ENSP00000385227
InnateDB Gene IDBG-9462 (IL6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 12 [view]
Protein-DNA 18 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
Biological Process
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR003573 Interleukin-6/Interleukin-23/GCSF/MGF
IPR003574 Interleukin-6
IPR009079 Four-helical cytokine-like, core
PFAM PF00489
PRINTS PR00433
PR00434
PIRSF PIRSF001935
SMART SM00126
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL C9J5B0
UniProt Splice Variant
Entrez Gene 3569
UniGene
RefSeq XP_005249802
HUGO HGNC:6018
OMIM 147620
CCDS
HPRD 00970
IMGT
EMBL AC073072 AK298077
GenPept BAG60365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca