Version 5.4
Homo sapiens Protein: CDCA7L
Summary
InnateDB Protein IDBP-294952.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCA7L
Protein Name cell division cycle associated 7-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383986
InnateDB Gene IDBG-9373 (CDCA7L)
Protein Structure
UniProt Annotation
Function Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269PubMed:15654081, ECO:0000269PubMed:15994933, ECO:0000269PubMed:16829576}.
Subcellular Localization Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Disease Associations
Tissue Specificity Ubiquitous. Overexpressed in medulloblastoma. {ECO:0000269PubMed:15654081, ECO:0000269PubMed:15994933}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1
PFAM PF10497
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96GN5
PhosphoSite PhosphoSite-Q96GN5
TrEMBL C9JFL7
UniProt Splice Variant
Entrez Gene 55536
UniGene Hs.520245
RefSeq NP_061189
HUGO HGNC:30777
OMIM 609685
CCDS CCDS5374
HPRD 11481
IMGT
EMBL AC074379 AC099653 AK022955 AK095965 AK300781 AL359619 AY161168 AY161169 BC009352 BC014630 BC025242 BC032576 BC039823 CH236948 CH471073
GenPept AAH09352 AAH14630 AAH25242 AAH32576 AAH39823 AAO17570 AAO17571 BAB14330 BAG53177 BAG62445 CAB94887 EAL24271 EAW93741 EAW93743 EAW93744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca