InnateDB Protein
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IDBP-295055.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FHL2
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Protein Name
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four and a half LIM domains 2
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Synonyms
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AAG11; DRAL; FHL-2; SLIM-3; SLIM3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386633
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InnateDB Gene
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IDBG-64511 (FHL2)
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Protein Structure
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Function |
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. {ECO:0000269PubMed:15692560, ECO:0000269PubMed:16652157, ECO:0000269PubMed:18853468}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in skeletal muscle and heart. {ECO:0000269PubMed:11813260}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
115
[view]
|
Protein-Protein |
113
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0009725
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response to hormone
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GO:0030521
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androgen receptor signaling pathway
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GO:0043066
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negative regulation of apoptotic process
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q14192
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PhosphoSite |
PhosphoSite-Q14192
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TrEMBL |
Q6I9R8
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UniProt Splice Variant |
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Entrez Gene |
2274
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UniGene |
|
RefSeq |
XP_005263963
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HUGO |
HGNC:3703
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OMIM |
602633
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CCDS |
CCDS2070
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HPRD |
04026
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IMGT |
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EMBL |
AB038794
AC012360
AC068273
AC108058
AK313841
BC012742
BC014397
BC093049
BT006960
CH471127
CR457437
DQ307067
L42176
U29332
U60117
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GenPept |
AAA85333
AAC50794
AAC52073
AAH12742
AAH14397
AAH93049
AAP35606
AAY14896
AAY15012
ABC25549
BAA92253
BAG36573
CAG33718
EAX01758
EAX01759
EAX01760
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