InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTCF

Summary

InnateDB Protein

IDBP-295226.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTCF

Protein Name

CCCTC-binding factor (zinc finger protein)

Synonyms

MRD21;

Species

Homo sapiens

Ensembl Protein

ENSP00000384707

InnateDB Gene

IDBG-36980 (CTCF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	54 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043035	chromatin insulator sequence binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007059	chromosome segregation
GO:0010628	positive regulation of gene expression
GO:0016568	chromatin modification
GO:0016584	nucleosome positioning
GO:0040029	regulation of gene expression, epigenetic
GO:0040030	regulation of molecular function, epigenetic
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0070602	regulation of centromeric sister chromatid cohesion