InnateDB Protein
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IDBP-295337.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHMP3
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Protein Name
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charged multivesicular body protein 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387045
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InnateDB Gene
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IDBG-59881 (CHMP3)
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Protein Structure
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Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269PubMed:14505570, ECO:0000269PubMed:15707591, ECO:0000269PubMed:16740483, ECO:0000269PubMed:17331679, ECO:0000269PubMed:18076377}.
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Subcellular Localization |
Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane {ECO:0000305}. Note=Localizes to the midbody of dividing cells.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:15632132}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005024
Snf7
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PFAM |
PF03357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y3E7
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PhosphoSite |
PhosphoSite-Q9Y3E7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51652
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UniGene |
Hs.591582
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RefSeq |
NP_001180446
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HUGO |
HGNC:29865
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OMIM |
610052
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CCDS |
CCDS54375
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HPRD |
15650
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IMGT |
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EMBL |
AC015971
AC064848
AC068288
AF151907
AF219226
AK290725
AK294389
AK312353
AK315835
AY364249
BC004419
CH471053
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GenPept |
AAD34144
AAF26737
AAH04419
AAQ76808
AAX93078
AAY24211
BAF83414
BAF98726
BAG35273
BAG57645
EAW99448
EAW99449
EAW99450
EAW99451
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