InnateDB Protein
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IDBP-295339.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KDM3A
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Protein Name
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lysine (K)-specific demethylase 3A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386660
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InnateDB Gene
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IDBG-59796 (KDM3A)
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Protein Structure
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Function |
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269PubMed:16603237}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003347
JmjC domain
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PFAM |
PF02373
PF08007
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PRINTS |
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PIRSF |
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SMART |
SM00558
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4C1
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PhosphoSite |
PhosphoSite-Q9Y4C1
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TrEMBL |
C9JC73
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UniProt Splice Variant |
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Entrez Gene |
55818
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UniGene |
Hs.665536
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RefSeq |
XP_006712114
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HUGO |
HGNC:20815
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OMIM |
611512
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CCDS |
CCDS1990
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HPRD |
11054
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IMGT |
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EMBL |
AB018285
AC068288
AL832150
BX640698
CH471053
CR749581
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GenPept |
AAY24210
BAA34462
CAE45820
CAH18373
CAH18459
EAW99453
EAW99456
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