InnateDB Protein
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IDBP-29566.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ECSIT
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Protein Name
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ECSIT homolog (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000270517
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InnateDB Gene
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IDBG-29564 (ECSIT)
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Protein Structure
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Function |
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:17344420}. Nucleus {ECO:0000269PubMed:17344420}. Mitochondrion {ECO:0000269PubMed:17344420}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
53
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0004871
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signal transducer activity
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GO:0005515
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protein binding
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GO:0016651
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oxidoreductase activity, acting on NAD(P)H
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Biological Process |
GO:0001707
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mesoderm formation
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0007178
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transmembrane receptor protein serine/threonine kinase signaling pathway
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GO:0030509
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BMP signaling pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0051341
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regulation of oxidoreductase activity
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GO:0055114
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oxidation-reduction process
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Cellular Component |
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PDB ID |
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InterPro |
IPR010418
ECSIT
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PFAM |
PF06239
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BQ95
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PhosphoSite |
PhosphoSite-Q9BQ95
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TrEMBL |
K7EPL5
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UniProt Splice Variant |
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Entrez Gene |
51295
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UniGene |
Hs.738470
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RefSeq |
NP_057665
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HUGO |
HGNC:29548
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OMIM |
608388
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CCDS |
CCDS12262
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HPRD |
12225
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IMGT |
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EMBL |
AC008481
AF243044
BC000193
BC005119
BC008279
CR457204
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GenPept |
AAF62100
AAH00193
AAH05119
AAH08279
CAG33485
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