Version 5.4
Homo sapiens Protein: ECSIT
Summary
InnateDB Protein IDBP-29568.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECSIT
Protein Name ECSIT homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252440
InnateDB Gene IDBG-29564 (ECSIT)
Protein Structure
UniProt Annotation
Function Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17344420}. Nucleus {ECO:0000269PubMed:17344420}. Mitochondrion {ECO:0000269PubMed:17344420}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0051341 regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR010418 ECSIT
PFAM PF06239
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ95
PhosphoSite PhosphoSite-Q9BQ95
TrEMBL K7EPL5
UniProt Splice Variant
Entrez Gene 51295
UniGene Hs.738470
RefSeq NP_001135936
HUGO HGNC:29548
OMIM 608388
CCDS CCDS45980
HPRD 12225
IMGT
EMBL AC008481 AF243044 BC000193 BC005119 BC008279 CR457204
GenPept AAF62100 AAH00193 AAH05119 AAH08279 CAG33485

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca