Version 5.4
Homo sapiens Protein: PBRM1
Summary
InnateDB Protein IDBP-295702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PBRM1
Protein Name polybromo 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386529
InnateDB Gene IDBG-39289 (PBRM1)
Protein Structure
UniProt Annotation
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. {ECO:0000269PubMed:21248752}.
Subcellular Localization Nucleus.
Disease Associations Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. {ECO:0000269PubMed:21248752}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12487023}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0000228 nuclear chromosome
Protein Structure and Domains
PDB ID
InterPro IPR001025 Bromo adjacent homology (BAH) domain
IPR001487 Bromodomain
IPR009071 High mobility group box domain
PFAM PF01426
PF00439
PF00505
PF09011
PRINTS PR00503
PIRSF
SMART SM00439
SM00297
SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86U86
PhosphoSite PhosphoSite-Q86U86
TrEMBL Q9NVM2
UniProt Splice Variant
Entrez Gene 55193
UniGene Hs.734413
RefSeq XP_005265345
HUGO HGNC:30064
OMIM 606083
CCDS
HPRD
IMGT
EMBL AC104446 AC112215 AF177387 AF197569 AF225870 AF225871 AF225872 AK001507 AK056541 AY281068 BC015323 BC089409 BC115009 BC115010 BC115011 BC129934 BC129935
GenPept AAG34760 AAG48933 AAG48939 AAG48940 AAG48941 AAH15323 AAH89409 AAI15010 AAI15011 AAI15012 AAI29935 AAI29936 AAP34197 BAA91728 BAB71210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca