Version 5.4
Homo sapiens Protein: TBC1D10B
Summary
InnateDB Protein IDBP-295721.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D10B
Protein Name TBC1 domain family, member 10B
Synonyms EPI64B;
Species Homo sapiens
Ensembl Protein ENSP00000386538
InnateDB Gene IDBG-26054 (TBC1D10B)
Protein Structure
UniProt Annotation
Function Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269PubMed:16923811, ECO:0000269PubMed:19077034}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16923811}. Note=In melanocytes, located at the periphery of cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000195 Rab-GTPase-TBC domain
PFAM PF00566
PRINTS
PIRSF
SMART SM00164
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4KMP7
PhosphoSite PhosphoSite-Q4KMP7
TrEMBL
UniProt Splice Variant
Entrez Gene 26000
UniGene Hs.632182
RefSeq NP_056342
HUGO HGNC:24510
OMIM 613620
CCDS CCDS10676
HPRD 10892
IMGT
EMBL AB449895 AC106782 AF370370 AK002101 AK023192 AL117408 BC050523 BC063112 BC072453 BC093814 BC093816 BC098419 CH471192
GenPept AAH50523 AAH63112 AAH72453 AAH93814 AAH93816 AAH98419 AAQ15206 BAA92086 BAB14454 BAH16638 CAB55908 EAW52256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca